Narcolepsy and Hypersomnia
نویسندگان
چکیده
منابع مشابه
Causes of Hypersomnia – Narcolepsy
Volitional sleep deprivation and obstructive sleep apnea are the most common causes of hypersomnia. The remaining causes are primarily due to p r imary cen t r a l ne rvous sys t em abnormalities, the most common of which is narcolepsy, a primary disorder of the neural control of wakefulness and sleep.
متن کاملIgG Abnormality in Narcolepsy and Idiopathic Hypersomnia
BACKGROUND A close association between narcolepsy and the Human Leukocyte Antigen (HLA)-DQB1*0602 allele suggests the involvement of the immune system, or possibly an autoimmune process. We investigated serum IgG levels in narcolepsy. METHODOLOGY/PRINCIPAL FINDINGS We measured the serum total IgG levels in 159 Japanese narcolepsy-cataplexy patients positive for the HLA-DQB1*0602 allele, 28 id...
متن کاملSuccessful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for...
متن کاملHypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions to rapid eye movement sleep, opens a new field of investigation in the area of disorders of sleep and activation. Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) (also called orexin-A and orexin-B) are newly discovered neuropeptides proce...
متن کاملIncreased REM density in narcolepsy-cataplexy and the polysymptomatic form of idiopathic hypersomnia.
The present work is focused on REM sleep density in patients with primary hypersomnia in comparison with non-hypersomnia subjects. 28 unmedicated patients with narcolepsy-cataplexy (NC) and 10 unmedicated patients suffering from the polysymptomatic form of idiopathic hypersomnia (IH) and their age- and sex-matched controls were included in the study. The clinical diagnosis was confirmed by MSLT...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1981
ISSN: 0022-3050
DOI: 10.1136/jnnp.44.9.855